Transdermal drug delivery systems provide an easy reliable mechanism of administering drugs when rapid onset is not important transdermal drug delivery bypasses the enterohepatic circulation thereby providing a more reliable clinical action with many drugs the efficacy of transdermal delivery is equivalent to that of a continuous iv infusion yet in a noninvasive system. Transdermal drug delivery system has been in existence for a long time in the past the most commonly applied systems were topically applied creams and ointments for dermatological disorders the occurrence of systemic side effects with some of these formulations is indicative of absorption through the skin a number of drugs have been applied to the skin for systemic treatment in a broad . First generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small lipophilic low dose drugs second generation delivery systems using chemical enhancers noncavitational ultrasound and iontophoresis have also resulted in clinical products the ability of iontophoresis to control delivery rates in real time provides added functionality . Chemical technology review no 228 responsibility edited by da jones reviews user contributed reviews tags add tags for transdermal and related drug delivery systems be the first similar items related subjects 17 transdermal medication dermatologic agents administration topical dermatologic agents patents as topic pharmaceutical preparations administration dosage . Transdermal drug delivery system a review richa sachan meenakshi bajpai uttarakhand technical university dehradun 248001 corresponding author email richapsit2009gmailcom received september 072013 accepted november 01 2013 abstract delivery of drugs through the skin has been always a challenging area for research due to barrier properties exhibit by the outermost layer of skin
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